Transmembrane emp24 domain-containing protein 7 (TMED7)

Transmembrane emp24 domain-containing protein 7 (TMED7) is a member of the p24/TMED protein family, characterized by a single transmembrane domain and a luminal Golgi-dynamics (GOLD) domain[5][2]. TMED7 is primarily localized to the Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment, where it plays a key role in vesicular trafficking and cargo selection as part of the early secretory pathway[3][5]. It regulates the biosynthesis, processing, and post-translational modification of secreted proteins, functioning as a cargo receptor and participating in quality control of protein folding[3][5]. Additionally, TMED7 is involved in the negative regulation of toll-like receptor 4 (TLR4) signaling upon lipopolysaccharide stimulation, influencing innate immune responses by facilitating degradation of TLR4 and inhibiting specific (MyD88-independent) downstream pathways[2]. TMED7, like other TMED family members, may also have broader roles in disease, including congenital glycosylation disorders, cancer, inflammation, and neurodegenerative disease, by influencing protein trafficking and immune signaling[5][3][2]. No known drugs or targeted inhibitors are currently associated with TMED7.

Other names

Transmembrane p24 trafficking protein 7CGI-109p24gamma3FLJ90481p24g3p24 family protein gamma-3p27Tagtransmembrane emp24 protein transport domain containing 7