Transmembrane gamma-carboxyglutamic acid protein 2 (PRRG2)

Transmembrane gamma-carboxyglutamic acid protein 2 (PRRG2) is a membrane protein encoded by the PRRG2 gene. It comprises an N-terminal gamma-carboxyglutamic acid (Gla) domain, typically exposed extracellularly, and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at the C-terminal, which are cytoplasmic. The PY motifs interact with WW domain-containing proteins (e.g., YAP1), suggesting a possible role in intracellular signal transduction and protein-protein interactions. PRRG2 is widely expressed as a single-pass transmembrane protein but is not currently classified as a therapeutic target, receptor, enzyme, or transporter. While genetic studies link the PRRG2 locus to certain syndromes and vitamin K-dependent pathways, its direct molecular or clinical function remains unclear[1][2][6][7].

Other names

Proline-rich and Gla domain 2PRRG2TMG2PRGP2Proline-rich gamma-carboxyglutamic acid protein 2Transmembrane gamma-carboxyglutamic acid protein 2Proline-rich Gla protein 2

Not applicable; since no drugs interact with PRRG2, mechanisms for drug modulation are not described[2][6][7].