Transmembrane p24 trafficking protein 2 (TMED2)

Transmembrane p24 trafficking protein 2 (TMED2) is a member of the TMED/p24 protein family, which regulates the trafficking of proteins between the endoplasmic reticulum (ER) and the Golgi apparatus. TMED2 serves as a cargo receptor, important for the selection and packaging of cargo into vesicles coated with COPI and COPII proteins. It is involved in both anterograde (ER to Golgi) and retrograde (Golgi to ER) transport, mainly by interacting with other TMED family members such as TMED10, and is implicated in the organization of secretory pathway organelles and in maintaining Golgi structure. TMED2 impacts the regulation of G protein-coupled receptor (GPCR) trafficking, innate immune signaling such as the STING/MITA pathway, and overall quality control of protein folding. Dysregulation or mutation of TMED2 is implicated in a wide range of diseases, especially different cancers, congenital disorders, cardiomyopathy, and immune dysfunction[1][3][4]. TMED2 is potentially a therapeutic target, but direct pharmacological modulators are not yet available, and manipulation may have systemic effects due to its fundamental role in protein secretion and cellular homeostasis.

Other names

TMED2p24 beta subunitp24 protein family member betaTransmembrane emp24 domain-containing protein 2

No direct mechanisms of drug action targeting TMED2 are annotated; therapeutic modulation would presumably target trafficking or inflammatory pathways.