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Transmembrane phosphatase with tensin homology (TPTE)
- Target
- TPTE
- Molecular classification
- Protein Tyrosine Phosphatases (PTPs), PTEN-related, Membrane-associated enzyme
01
Overview
Transmembrane phosphatase with tensin homology (TPTE) is a primate-specific member of the protein tyrosine phosphatase (PTP) family, closely related to PTEN. While structurally similar to active PTPs, TPTE is predicted to lack catalytic activity and may function as a regulatory or scaffolding protein. It is suggested to be involved in endocrine and spermatogenic functions, although its precise role remains unclear. TPTE is a paralog of TPTE2/TPIP.
- Other names
- CT44PTEN2transmembrane phosphatase with tensin homology
02
Mechanism of action
Not applicable, predicted inactive/lacks classical PTP activity
03
Biological functions
Signal transductionRegulation of inositol lipid signaling (potentially)Endocrine signaling (potentially)Spermatogenesis (potentially)Regulatory/scaffolding role
04
Disease associations
Unknown; potentially implicated in diseases related to endocrine or spermatogenic dysfunction.
05
Safety considerations
Limited understanding of physiological function raises potential safety concerns if targeted therapeutically.
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