Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (TPTE2)

Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (TPTE2) is an integral membrane enzyme related to the tumor suppressor PTEN, encoded by the TPTE2 gene (also known as TPIP). It acts as a lipid phosphatase, specifically removing the phosphate in the D3 position from phosphatidylinositol 3,4,5-trisphosphate (PIP3), thereby generating phosphatidylinositol 4,5-bisphosphate and inorganic phosphate[1][2][5]. TPTE2 is classified within the class I cysteine-based protein tyrosine phosphatases, and more specifically in the PTEN-like subgroup. Its enzymatic activity is important in regulating phosphoinositide signaling pathways, particularly those involved in cell growth, proliferation, and survival. TPTE2 is primarily localized to membranes such as the endoplasmic reticulum and Golgi, and is expressed across various tissues, with potential enrichment in reproductive organs based on the broader TPTE family[4][3]. Dysregulation of phosphoinositide metabolism, the pathway in which TPTE2 participates, is implicated in certain cancer syndromes (such as Cowden syndrome 1), but TPTE2 itself is not currently a therapeutic target of any approved drugs[1][2][5].

Other names

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2TPIPLipid phosphatase TPIPTPTE and PTEN homologous inositol lipid phosphatasePTEN-like inositol lipid phosphataseTPIP lipid phosphataseTransmembrane phosphoinositide 3-phosphatase and tensin 2-like protein