Transmembrane protease, serine 3 (TMPRSS3)

Transmembrane protease, serine 3 (TMPRSS3) is a type II transmembrane serine protease containing a serine protease domain, a transmembrane domain, a low-density lipoprotein receptor class A (LDLRA) domain, and a scavenger receptor cysteine-rich domain. It is essential for the survival and activation of cochlear hair cells and is required for proper hearing. TMPRSS3 mutations cause autosomal recessive nonsyndromic hearing loss (DFNB8/10). It is also expressed in various tissues and is overexpressed in some tumors, including ovarian cancer. TMPRSS3 is involved in proteolytic regulation of ion channels, particularly those important for auditory transduction and cochlear cell maintenance. No drugs specifically target TMPRSS3 clinically, but its genetic variants are used as diagnostic biomarkers for hereditary deafness syndromes.

Other names

ECHOS1TADG12UNQ323/PRO382Serine protease TADG-12Tumor-associated differentially-expressed gene 12 proteinDFNB10DFNB8transmembrane protease serine 3

Not directly drug-targeted; general mechanism is proteolysis of target proteins in cellular and extracellular contexts, impacting ion channel regulation and hair cell survival