Transmembrane protease serine 11D (TMPRSS11D)

Transmembrane protease serine 11D (TMPRSS11D) is a cell-surface, single-pass transmembrane serine protease most highly expressed in respiratory epithelium and other epithelial tissues. It belongs to the HAT/DESC subfamily of TTSPs and is active following autocleavage at its zymogen activation motif. TMPRSS11D is implicated in host defense, processing of proteins at epithelial barriers, and facilitating the entry of respiratory viruses such as SARS-CoV-2 and Influenza A/B into host cells. In cancer, TMPRSS11D expression promotes proliferation, migration, invasion, and epithelial–mesenchymal transition, correlating with poor prognosis and high-grade disease in several carcinomas. As a therapeutic target, TMPRSS11D is a focus for antiviral and anti-cancer agents, but inhibitor development is challenged by substrate specificity and protease redundancy across TTSPs.

Other names

TMPRSS11DHAT (Human Airway Trypsin-like protease)Airway trypsin-like proteaseAdrenal secretory serine proteaseASPTransmembrane serine protease 11D catalytic chainTransmembrane serine protease 11D non-catalytic chainDESC subfamily member

Inhibition of serine protease activity (blocking viral entry, tissue remodeling, and cancer progression by targeting substrate recognition or autocleavage site)