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Target intelligence / Profile preview
Transmembrane Protease Serine Type 2 (TMPRSS2)
- Target
- TMPRSS2
- Molecular classification
- Enzyme, Serine Protease, Type II Transmembrane Protein
01
Overview
Transmembrane protease serine type 2 (TMPRSS2) is a type II transmembrane serine protease that plays critical roles in both normal physiology and disease, particularly in viral infections and prostate cancer. It activates other proteins via proteolytic cleavage, facilitates entry of coronaviruses into host cells by cleaving their spike proteins, and is involved in prostate cancer development through gene fusions. It is highly expressed on epithelial surfaces including those lining airways/lungs and prostate glandular tissue.
02
Mechanism of action
Serine protease inhibition
03
Biological functions
ProteolysisPriming viral glycoproteinsRegulating sodium channelsEpithelial homeostasis
04
Disease associations
Prostate cancerCOVID-19/SARS/MERS susceptibilityViral infection
05
Interacting drugs
Camostat
1 more in the full profile.
06
Biomarkers
TMPRSS2-ERG fusion (prostate cancer)
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