Transmembrane protein 102 (TMEM102)

Transmembrane protein 102 (TMEM102) is a single-pass membrane protein located at the cell surface and is involved in intracellular signaling processes. Specifically, TMEM102 plays a role in the regulation of mitochondrial outer membrane permeabilization—an essential step in the intrinsic apoptotic pathway—and is selectively involved in apoptosis induced by colony stimulating factor 2 (CSF2) deprivation, highlighting a mitochondria-dependent mechanism. It also participates in cellular responses to cytokines and in processes like T cell migration and cell adhesion, indicating involvement in immune regulation. TMEM102 is not recognized as a classical drug target (such as a receptor, transporter, or enzyme), and no drugs targeting this protein have been reported in public sources. TMEM102 has alternative names (CBAP, D2B, etc.) but there is no evidence of widespread use of these compared to "TMEM102". The protein is not classified into one of the principal drug target families such as receptors, ion channels, or enzymes, but is a transmembrane protein of undefined specific family. While two parasitic diseases are listed as associated (hymenolepiasis and diphyllobothriasis), these are database associations and do not indicate any direct role as a disease driver. No evidence was found for its use as a biomarker, nor are there approved or investigational drugs directly targeting TMEM102. Functional data for molecular interactions beyond cell biology signaling is sparse.

Other names

CBAPFLJ36878D2BCommon beta-chain associated proteinDANGER family member 2Bcommon beta-chain-associated protein

None documented