Transmembrane protein 11, mitochondrial (TMEM11)

Transmembrane protein 11, mitochondrial (TMEM11) is an integral protein primarily localized to the outer mitochondrial membrane, where it plays a critical role in maintaining mitochondrial architecture and regulating mitochondrial dynamics, particularly the balance between mitochondrial fission and fusion[2][3]. TMEM11 interacts with proteins of the MICOS complex (mitochondrial contact site and cristae organizing system) and mitophagy regulators BNIP3 and BNIP3L, thereby influencing the spatial activation of mitophagy, especially under stress conditions such as hypoxia[2]. Disruption or depletion of TMEM11 leads to loss of mitochondrial tubular morphology, enlargement or fragmentation of mitochondria, impaired cristae structure, and can negatively impact cellular and organismal physiology, including neuronal function and cardiomyocyte proliferation in model organisms[1][2][3]. While TMEM11 is critical for mitochondrial integrity, it is not currently considered a direct therapeutic target (such as an enzyme or receptor) and no interacting drugs or established biomarker applications have been identified in the literature as of the current date[2][3].

Other names

C17orf35Pantagruelian Mitochondrion I (PMI)PM1Protein PMIProtein PM1transmembrane protein 11, mitochondrialputative receptor protein