Transmembrane protein 128 (TMEM128)

Transmembrane protein 128 (TMEM128) is a membrane protein encoded by the TMEM128 gene located on chromosome 4p16.3 in humans[2]. It exists in at least two major isoforms, both containing four transmembrane helices and localizing predominantly to the endoplasmic reticulum membrane, with both termini in the cytoplasm[2][4]. The biological function of TMEM128 remains poorly understood; however, it is known to interact with several proteins involved in cell cycle control (such as GRB2, BCL2L13), memory (Arc/Arg3.1), apoptosis, ER function (reticulons RTN2/RTN4, REEP5/REEP6), and vesicle transport[2][4]. Post-translational regulation is extensive, including multiple phosphorylation, glycation, SUMOylation, acetylation, and O-GlcNAc modification sites[2]. Its expression shows tissue specificity, with higher expression in the adrenal gland and spinal cord[2]. Clinical studies associate TMEM128 with a range of cancers (but with low specificity) and certain neurological and muscle-related conditions; its gene region is notable in Wolf-Hirschhorn syndrome, though it is not established as a causal gene[2][5]. TMEM128 is not currently regarded as a therapeutic target, and there are no approved drugs or biomarker roles established for it. Current knowledge of TMEM128 is strongly limited, and there is no evidence that it functions as a conventional drug target, receptor, transporter, or enzyme[2][3][5].

Other names

TMEM128MGC13159zgc:110421zmp:0000001107