Transmembrane protein 132B pseudogene

The transmembrane protein 132B pseudogene (ENSG00000256502) is a non-protein-coding DNA sequence derived from a duplication or retrotransposition event related to the TMEM132B gene[1][3]. Pseudogenes are typically characterized by sequence disablements, such as premature stop codons or frameshifts, which prevent their translation into functional proteins[1][3][4]. While most pseudogenes are considered genetic relics without direct biological activity, rare cases may involve transcriptional activity that influences their parent genes through mechanisms such as competing endogenous RNA or sequence exchange, potentially affecting gene regulation or disease susceptibility[4][5]. However, there is no evidence in current literature that this specific pseudogene (ENSG00000256502) plays an active biological or disease role. ENSG00000256502 represents a pseudogene for the transmembrane protein 132B—not a conventional drug target, receptor, enzyme, or transporter. It does not produce a functional protein, does not have disease-specific roles, and should not be considered in the same context as the protein-coding gene TMEM132B. This entry is therefore not suitable for structured therapeutic target information. Pseudogenes may occasionally affect molecular diagnostics due to sequence homology, but otherwise have minimal direct impact[5].