Transmembrane protein 132D (TMEM132D)

Transmembrane protein 132D is a cell-surface adhesion molecule that is highly expressed in the brain and mature oligodendrocytes[1][3]. It features five conserved extracellular domains, including three tandem immunoglobulin domains and a cohesin domain homologue, marking it as part of an ancient and structurally unique cell adhesion protein family[1]. Its intracellular domain contains docking sites for protein phosphatase 1 (PP1) and a WAVE regulatory complex interacting motif, linking extracellular neuronal interactions to actin cytoskeleton dynamics[1]. TMEM132D is implicated in the regulation of neuronal morphology, motility, and migration, and has been associated with several diseases, including panic disorder, non-syndromic hearing loss, and cancer[1]. Its domain architecture and evolutionary conservation suggest physiologically significant roles in CNS cell connectivity and response to genetic variants, warranting deeper investigation as a disease-related target[1][3].

Other names

TMEM132DHBE120KIAA1944MOLTPPP1R153Mature oligodendrocytes transmembrane proteinMature OL transmembrane proteinProtein phosphatase 1 regulatory subunit 153

Not established; since no approved drugs target TMEM132D directly, no mechanisms have been characterized.