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Transmembrane protein 139 (TMEM139)

Target: TMEM139
Molecular classification: Other (single-pass transmembrane protein)

Overview

Transmembrane protein 139 (TMEM139) is a single-pass membrane protein primarily known for its predicted role in mediating the trafficking of specific proteins, such as SLC4A1 (anion exchanger 1); it may interact with E-cadherin and inhibit its lysosomal degradation, a function implicated in the suppression of non-small cell lung cancer metastasis[2][3][6][7]. The gene is located on human chromosome 7 and is expressed across multiple tissues, but detailed functional information remains limited, and it is not currently established as a therapeutic target for any disease[1][2][4][7]. Genetic association studies link TMEM139 mutations with some forms of cancer and congenital neutropenia, but these roles are still being investigated[2][6].

Other names: FLJ90586GC07P142687 (and numerous previous GeneCards short identifiers)

Biological functions

Cellular trafficking of certain proteins (predicted, including SLC4A1 - anion exchanger 1)Inhibition of lysosomal degradation of E-cadherin (reported in some cancer studies)

Disease associations

Cancer (specifically, associations with non-small cell lung cancer (NSCLC) metastasis inhibition and potentially gastric adenosquamous carcinoma)Neutropenia, severe congenital, X-linked (association based on genetic data)

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