Transmembrane protein 141 (TMEM141)

Transmembrane protein 141 (TMEM141) is a small, multi-pass integral membrane protein encoded by the TMEM141 gene in humans (UniProt Q96I45), with a molecular mass of ~11.9 kDa. It is mainly localized to the mitochondrion and expressed in various tissues, with notable abundance in endothelial cells, neurons, and most glandular tissues. Orthologs exist in model organisms (e.g., Drosophila), sharing mitochondrial localization. TMEM141’s function remains uncharacterized: no established role in signal transduction, cell cycle, or other canonical membrane protein functions has been reported. Although related TMEM family genes have been implicated in cancer and immune regulation, there is no evidence that TMEM141 directly participates in those processes. Rare biallelic loss-of-function variants can cause neurodevelopmental disorders in humans, and Mendelian disease association includes arthrogryposis multiplex congenita-3. No currently approved or investigational drugs target TMEM141, and it is not used as a diagnostic or predictive biomarker.

Other names

TMEM141MGC14141

Not applicable