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Transmembrane protein 143 (TMEM143)

Target: TMEM143
Molecular classification: Other (transmembrane protein with no evidence of being a classic receptor, enzyme, ion channel, or transporter[2][4][1])

Overview

Transmembrane protein 143 (TMEM143) is a dual-pass transmembrane protein primarily localized to the mitochondrial membrane, with possible presence in the plasma membrane and other organelles[2][1]. It is highly expressed in human heart and skeletal muscle, and predicted functions include acting upstream in hematopoietic progenitor cell differentiation and serving a linker or scaffold role at organelle contact sites[1][3][4]. TMEM143 is not currently classified as a typical therapeutic target such as a receptor, enzyme, or transporter, nor are there any approved pharmaceutical agents directed at it. Expression and interaction studies suggest a potential, but unproven, role in cancer regulation and lipid metabolism[2]. It has several aliases and is conserved across vertebrates. Due to a lack of clear mechanistic or disease-association evidence, TMEM143 is not considered a therapeutic target at this time[2][4][1].

Other names: TMEM143UNQ5922/PRO19813FLJ10922Transmembrane protein 143

Biological functions

Hematopoietic progenitor cell differentiation[1][4]Protein binding[3]Possible involvement in lipid metabolism and adipocyte differentiation through PPARγ pathways[2]Mitochondrial membrane localization and possible linker/scaffold function at organelle contact sites[3]

Disease associations

Possible tumor suppression/cancer regulation suggested by its chromosomal region and protein interactions, but not established as a direct disease target[2]Detected genomic loss region in malignant gliomas, neuroblastomas, ovarian carcinomas, but its direct contribution remains unclear[2]

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