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Transmembrane protein 145 (TMEM145)
- Target
- TMEM145
- Molecular classification
- Other (Predicted member of the GOST [GOLD-domain seven-transmembrane helix] protein family), Transmembrane protein (Possesses a predicted seven-transmembrane domain, but does not meet criteria for canonical G protein-coupled receptor family), Transporter (some protein databases classify as such, but no clear functional evidence exists)
01
Overview
Transmembrane protein 145 (TMEM145) is a poorly characterized human membrane protein encoded by the TMEM145 gene (HGNC:26912; NCBI Gene: 284339)[3][5]. TMEM145 is predicted to contain a seven-transmembrane domain with homology to proteins of the GOST (GOLD-domain seven-transmembrane helix) superfamily, which includes TMEM87, GPR180, TMEM181, and Wntless (WLS)[4][6]. While structurally related to G protein-coupled receptors (GPCRs), TMEM145 and other GOST proteins lack crucial GPCR motifs and are likely not functional as classical receptors[4]. The biological function of TMEM145 in humans is unknown; it has been predicted (in silico) to participate in GPCR-related pathways and membrane trafficking, but these roles are not experimentally validated[1][3][4]. There are no known drugs or small molecules that target TMEM145, and no clinical applications have been developed. Expression and mutation data are available, but no disease causality has been firmly established[3][7].
- Other names
- TMEM145FLJ90805
02
Mechanism of action
None known
03
Biological functions
Unknown/Other (Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone, but no direct evidence of these roles)Protein localization to membranePotential involvement in membrane trafficking, by analogy with related proteins in the GOST family
04
Disease associations
Other (Limited data: may have some association with "Alternating Esotropia," a rare strabismus condition in GeneCards, but no strong established disease link)No confirmed roles in major diseases such as cancer, inflammation, or neurodegeneration as of current knowledge
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Safety considerations
None known
06
Interacting drugs
None known
07
Biomarkers
None known
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