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Transmembrane protein 14A (TMEM14A)

Target: TMEM14A
Molecular classification: Transmembrane protein, Other

Overview

Transmembrane protein 14A (TMEM14A) is an integral membrane protein containing three transmembrane domains, expressed in the endoplasmic reticulum membrane and mitochondrial membrane. It is involved in the negative regulation of mitochondrial outer membrane permeabilization, thereby suppressing apoptosis, most likely through inhibition of Bax-mediated mitochondrial permeabilization. TMEM14A has been implicated in biological processes related to cell survival and apoptosis, and is associated with diseases such as cancer and various forms of epilepsy.

Other names: C6orf73PTD011LOC1036932105730496E24RIK

Biological functions

Negative regulation of mitochondrial outer membrane permeabilizationApoptosis inhibitionCellular membrane organization

Disease associations

CancerEpilepsy (including myoclonic juvenile epilepsy and generalized epilepsy)Other possible roles in diverse tissues (based on expression data)

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