Transmembrane protein 151A (TMEM151A)

Transmembrane protein 151A (TMEM151A) is an evolutionarily conserved, multi-pass transmembrane protein encoded by the TMEM151A gene, located on chromosome 11q13.2. It comprises 468 amino acids and contains three predicted transmembrane domains with most of its structure oriented toward the cytoplasm. TMEM151A is an integral component of the endoplasmic reticulum membrane in humans and other vertebrates[4][7]. Its precise molecular function remains unknown, but findings from both genetic and functional studies implicate it in the pathogenesis of paroxysmal kinesigenic dyskinesia, a neurologic disorder characterized by involuntary movements[1][5][6][8]. While some evidence suggests it may have roles in ion channel activity or intracellular calcium signaling, this remains to be fully defined[7]. No established drug interactions, mechanisms of action, biomarkers, or therapeutic applications are documented for TMEM151A at present.

Other names

TMEM151MGC33486DYT36EKD3transmembrane protein 151TMEM151B (paralog)TMEM151A gene

None known