Transmembrane protein 169 (TMEM169)

Transmembrane protein 169 (TMEM169) is a membrane-bound protein encoded by the TMEM169 gene on human chromosome 2q35, with the protein product consisting of 297 amino acids and containing two transmembrane domains[2][1]. TMEM169 is expressed in various tissues, with highest levels in brain, especially fetal brain and glial cells[2][8]. Genetic evidence links the region containing TMEM169 to pulmonary phenotypes, and variants in this gene are associated with susceptibility to chronic obstructive pulmonary disease (COPD), neural tube defects, and preeclampsia, but the precise molecular function remains undetermined[1][2][7]. While TMEM169 is known to interact with RhoU (a small GTPase) and is regulated at both gene and protein levels, it is not currently considered a well-defined therapeutic target (such as receptor, enzyme, or transporter) and there are no known drugs or specific mechanisms of action involving this protein[2].

Other names

FLJ34263DKFZp781L2456LOC92691TMEM169[2][3][7]