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Target intelligence / Profile preview
Transmembrane protein 16A (ANO1)
- Target
- ANO1
- Molecular classification
- Ion channel, Calcium-activated chloride channel, Transmembrane protein
01
Overview
TMEM16A (ANO1) is a calcium-activated chloride channel involved in various physiological processes including transepithelial anion transport, smooth muscle contraction, and neuronal excitation. It is implicated in cancer progression and is a potential therapeutic target.
- Other names
- TMEM16ADOG1ORAOV2TAOS2Anoctamin-1
02
Mechanism of action
TMEM16A inhibition
03
Biological functions
Ion transportSmooth muscle contractionPacemakingEpithelial secretionNeuronal excitation
04
Disease associations
CancerHead and neck squamous cell carcinomaGastrointestinal stromal tumorsBreast cancerEsophageal cancerSmooth muscle contraction disorders
05
Safety considerations
Potential for off-target effects due to wide expressionEffects on normal physiological processesBicarbonate secretion modulation
06
Interacting drugs
Crofelemer
07
Biomarkers
DOG1 immunostaining (for GIST)TMEM16A overexpression
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