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Transmembrane protein 178A (TMEM178A)
- Target
- TMEM178A
- Molecular classification
- Transmembrane protein, Other
01
Overview
Transmembrane protein 178A (TMEM178A) is a membrane-associated protein encoded by the TMEM178A gene on chromosome 2. It acts as a negative regulator of osteoclast differentiation both in basal and inflammatory conditions, by modulating Ca(2+) fluxes induced by TNFSF11 (RANKL), and thus impacts activation of NFATC1, a key transcription factor in osteoclastogenesis. TMEM178A is localized predominantly to the endoplasmic reticulum membrane. There is some predicted involvement in the regulation of cytosolic calcium ion concentration, suggesting a broader modulatory role in intracellular signaling. While associated with bone metabolism and potentially with hereditary angioedema, it is not currently recognized as a therapeutic target or biomarker in clinical oncology, immunology, or metabolic disease
- Other names
- TMEM178ATMEM178PSEC0131UNQ5926/PRO19820MGC33926
02
Biological functions
Negative regulation of osteoclast differentiationRegulation of cytosolic calcium ion concentrationModulation of TNFSF11-induced Ca(2+) fluxes, affecting NFATC1 induction (osteoclastogenesis pathway)
03
Disease associations
Possible association with hereditary angioedema (not extensively characterized)Other (potential roles in bone metabolism regulation, but no strong evidence for specific disease causality)
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