Transmembrane protein 184A (TMEM184A)

Transmembrane protein 184A (TMEM184A) is a highly conserved integral membrane protein that acts as a heparin receptor in vascular endothelial and smooth muscle cells. It is involved in the regulation of angiogenesis by modulating endothelial cell proliferation. TMEM184A mediates anti-proliferative and anti-inflammatory signals in response to heparin, reducing MAPK signaling and vascular cell growth, and plays a potential role in vesicle transport, particularly in exocrine and Sertoli cells. The physiological function of TMEM184A continues to be characterized, and while it is not yet established as a direct therapeutic target in clinical practice, its essential role in angiogenesis suggests therapeutic relevance, especially in contexts of abnormal vascular proliferation.

Other names

MGC9712SDMG1SLC51C1sexually dimorphic, expressed in male gonads 1transmembrane protein 184A

Heparin binding to TMEM184A induces anti-proliferative and anti-inflammatory signaling in vascular endothelial and smooth muscle cells, leading to upregulation of DUSP1 and inhibition of MAPK/ERK signaling, resulting in reduced proliferation