Transmembrane protein 185B (TMEM185B)

Transmembrane protein 185B (TMEM185B) is a predicted seven-transmembrane orphan G protein-coupled receptor highly conserved across species, mainly expressed in the central nervous system, and upregulated by erythropoietin in neurons, which suggests involvement in integrative and motor neurological functions. It interacts with microtubule-associated protein MAP1b, affecting protein stability and possibly participating in serotonin receptor (5HT2a) modulation and trafficking. Its association with MHC Class II deficiency highlights a potential but not fully elucidated role in immune-related or neurological diseases. TMEM185B is categorized under protein coding genes, with strong membrane localization and predicted orphan GPCR structure. Interaction with MAP1b is crucial for proper folding and detection of TMEM185B, suggesting reliance on cytoskeletal processes. TMEM185B is evolutionarily conserved and mainly expressed in neurons, consistent with a specialized neuronal or synaptic regulatory function. Evidence for direct pharmacological targeting is limited, but interaction with (+)-schisandrin B in rats is documented. No confirmed biomarkers or critical safety liabilities have been published. Disease association is mainly based on gene linkage and expression studies, not well-established functional data.

Other names

FAM11BFLJ20979Protein FAM11Bee3_2family with sequence similarity 11 member Bputative transmembrane protein 185BTMEM185B (pseudogene)

Not fully defined, but may involve modulation of neuronal signaling and microtubule protein interactions