Transmembrane protein 186 (TMEM186)

Transmembrane protein 186 (TMEM186) is a mitochondrial transmembrane protein encoded by the TMEM186 gene, located on human chromosome 16[2][7][8]. TMEM186 is a component of the MCIA complex (mitochondrial complex I assembly), where it is required for the efficient assembly of mitochondrial complex I, crucial for cellular energy production through respiratory electron transport[2][3][4][9]. Variants of TMEM186 have been associated with rare congenital disorders of glycosylation and some aspects of mitochondrial disease, but its precise biological mechanisms remain to be fully characterized[2][6][9]. As of current knowledge, TMEM186 is not a druggable therapeutic target, has no validated biomarker role, and no direct pharmacological interactions are established. Its primary annotation in disease comes from genetic and pathway studies rather than clinical application[2][4][7][9].

Other names

TMEM186C16orf51DKFZP564K2062TM186_HUMAN (UniProt protein name)

None identified