Transmembrane protein 187 (TMEM187)

Transmembrane protein 187 (TMEM187) is a multi-pass membrane protein encoded by a gene located on the X chromosome (two exons), designated as TMEM187 (HGNC:13705, UniProt:Q14656)[3][5][6]. TMEM187 is widely expressed in various tissues, including the nervous system, and has been found in several organ systems. It is not a receptor, enzyme, transporter, or recognized drug target. TMEM187 has been implicated in several genetic diseases, including leukodystrophy and Galloway-Mowat syndrome 2[3]. Notably, TMEM187 interacts with known autism-associated proteins (HCFC1, TMLHE, MeCP2, and GPHN), suggesting a possible role in neurodevelopmental processes[6]. There is currently no evidence that TMEM187 functions as a receptor or is targeted by any approved therapeutics, nor are there validated mechanisms of action, biomarker utilities, or notable drug safety concerns. Its molecular classification is a generic multi-pass transmembrane protein with no evidence for ion channel, transporter, or GPCR activity. Its exact physiological or pathophysiological function remains incompletely defined[3][5][6].

Other names

CXorf12DXS9878EITBA1Protein ITBA1