Transmembrane protein 19 (TMEM19)

Transmembrane protein 19 (TMEM19) is a protein in humans encoded by the TMEM19 gene, located on chromosome 12q21.1[1][5]. The protein comprises 336 amino acids and features 6 transmembrane regions, with moderate expression in various tissues and highest levels reported in superior cervical ganglia and cardiac myocytes[1][4]. TMEM19 is annotated as a protein of unknown function (DUF92 family) and appears to associate with the cell membrane, with predicted activity based on computational models[3][5]. Associations have been made between TMEM19 genetic loci and non-syndromic cleft lip with palate as well as ammonia nitrogen tolerance, but no clear or direct therapeutic targeting roles or mechanistic disease implications have been established[1]. Protein–protein interaction data suggest TMEM19 interacts with a variety of membrane-associated proteins, but its precise function remains uncharacterized[1]. No known drugs or targeted therapies are reported, and there is no established role as a therapeutic target in the biomedical literature to date[1][3][5].

Other names

TMEM19FLJ10936transmembrane protein 19