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Transmembrane protein 204 (TMEM204)
- Target
- TMEM204
- Molecular classification
- Other (Transmembrane protein, Claudin-like protein)
01
Overview
Transmembrane protein 204 (TMEM204) is a multi-pass transmembrane protein encoded by the TMEM204 gene located on chromosome 16 (also known as C16orf30). TMEM204 is classified as a claudin-like protein and is implicated in regulating cell adhesion and cellular permeability specifically at adherens junctions, influencing paracellular transport between cells. Functional studies suggest roles in lymph vessel development, smooth muscle cell differentiation, and modulation of signaling pathways important in vascular biology. Although TMEM204’s protein structure and subcellular localization have been characterized, there is limited evidence for its involvement as a therapeutic target or disease biomarker at present.
- Other names
- C16orf30CLP24Claudin-like protein 24FLJ20898Claudin-like protein of 24 kDaUNQ6509/PRO21434
02
Biological functions
Cell adhesionRegulation of cellular permeabilityCell-cell interactions through adherens junctionsLymph vessel developmentSmooth muscle cell differentiationRegulation of vascular endothelial growth factor receptor signaling pathway
03
Disease associations
Limited evidence for direct involvement in disease; some association with syndromic X-linked intellectual disability (Nascimento type)Other (currently, the gene is not a well-established disease target)
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