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Transmembrane protein 229A (TMEM229A)
- Target
- TMEM229A
- Molecular classification
- Transmembrane protein, Other
01
Overview
Transmembrane protein 229A (TMEM229A) is an integral membrane protein predicted to contain multiple transmembrane domains. Its expression is significantly reduced in non-small cell lung cancer, and low TMEM229A levels are associated with poor patient prognosis. Overexpression of TMEM229A suppresses EMT, enhances E-cadherin expression, decreases N-cadherin and related metastasis markers, and inhibits cell proliferation, migration, and invasion. It negatively regulates ERK and AKT signaling pathways, suggesting a potential role as a tumor suppressor and molecular target in lung cancer biology[1][2][3].
- Other names
- TMEM229Atransmembrane protein 229A
02
Mechanism of action
No drugs have established mechanisms of action on TMEM229A; therapeutic strategies may involve gene overexpression or modulation of related signaling pathways[1].
03
Biological functions
Inhibition of epithelial-mesenchymal transition (EMT)Suppression of cell proliferation, migration, invasionRegulation of ERK and AKT signaling pathways in NSCLC
04
Disease associations
Cancer (specifically NSCLC; reduced expression correlated with poor prognosis)
05
Biomarkers
Low TMEM229A expression
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