Transmembrane protein 229B (TMEM229B)

Transmembrane protein 229B (TMEM229B) is a 167-amino acid membrane protein encoded by the TMEM229B gene on chromosome 14q24.1 in humans[2][9]. It contains a DUF1113 (domain of unknown function) and is predicted based on sequence analysis to adopt a structural fold similar to connexin 4-pass transmembrane subunits but lacks a characterized physiological or molecular function[2]. TMEM229B is ubiquitously expressed throughout many human tissues, with highest levels in parathyroid, skin, and thyroid[2]. Increased expression is observed in several neoplastic disease states, including various cancers and lymphomas, but there is no evidence it is causative of these diseases[2]. TMEM229B has not been definitively identified as a therapeutic target (such as a receptor, transporter, or enzyme), and there are no known drugs targeting this protein[2][4]. There are no established roles for TMEM229B as a biomarker or specific safety concerns reported in the literature[2][4].

Other names

TMEM229BC14orf83FLJ33387Q8NBD8Hs.509707Hs.712258transmembrane protein 229BCN083_HUMAN