Transmembrane protein 233 (TMEM233)

Transmembrane protein 233 (TMEM233) is an accessory transmembrane protein primarily expressed in sensory neurons, classified within the dispanin subfamily B family. TMEM233 is required for the pharmacological and toxicological effects of certain plant-derived peptide toxins, notably ExTxA, on the voltage-gated sodium channel NaV1.7, a critical component in nociceptive (pain-sensing) neurons. TMEM233 binds these toxins and, in conjunction with NaV1.7, alters the channel’s inactivation properties, promoting persistent sodium currents and increased cellular excitability. Its structure includes at least one membrane-spanning domain with extracellular C-terminus and intracellular N-terminus. Genetic association studies list TMEM233 in the context of osteogenesis imperfecta type V, but its primary characterized physiological and pathological function relates to pain modulation and sodium channel accessory protein function[1][2][4][5].

Other names

IFITMD2DSPB2Dispanin subfamily B member 2Interferon-induced transmembrane domain-containing protein D2Interferon induced transmembrane protein domain containing 2

Modulation of sodium channel (NaV1.7) gating through physical interaction enabling toxin (ExTxA) action