Transmembrane protein 235 (TMEM235)

Transmembrane protein 235 (TMEM235) is a human protein-coding gene located on chromosome 17 (17q25.1), predicted to encode a glycosylated transmembrane protein of unclear function[3][5]. It is not a member of the claudin family, despite some past naming confusion[2]. TMEM235 is expressed in multiple tissues, including the brain, gut, heart, liver, and kidney, and has at least six transcript variants[3][4]. Its inferred localization is the apical plasma membrane and endoplasmic reticulum. One study associates TMEM235 with the disease cataract, but its precise molecular and physiological roles remain unknown[5]. Functional annotation is limited to predicted structural molecule activity, and there is currently no evidence supporting its use as a therapeutic target, biomarker, or clinical drug interaction partner. Clarification of Alias Usage: The term "claudin-27" has been used as a synonym, but current molecular databases (e.g., InterPro, UniProt, GeneCards) separate TMEM235 from claudin family members and this synonym should be considered deprecated or incorrect in modern usage[2][5]. Summary: TMEM235 is a predicted membranous structural protein, not currently considered a therapeutic target, druggable entity, or biomarker. Its functional, pharmacological, and pathological roles are largely unknown[5][2][3].

Other names

TMEM235Transmembrane protein 235ENSP00000364084HGNC:27563NCBI Gene:283999UniProt A6NFC5OMIM:620272Claudin-27ARGM1