Transmembrane protein 243 (TMEM243)

Transmembrane protein 243 (TMEM243) is a small protein of 118 amino acids predominantly localized to the membrane, with specific accumulation in the mitochondria[1][10]. TMEM243 is overexpressed in certain taxol- and doxorubicin-resistant cancer cell lines, where its induction corresponds to drug exposure and is co-expressed with MDR1, a well-established drug efflux transporter. While TMEM243 does not belong to major drug target families such as G-protein coupled receptors, ion channels, enzymes, or nuclear receptors, its role in mitochondrial function and drug resistance pathways suggests potential relevance in cancer biology, but it is not currently a known therapeutic target[1][2][10]. There are no approved drugs that directly inhibit or modulate TMEM243, nor is it established as a validated biomarker or drug target.

Other names

C7orf23MM-TRAGMMTRAGMGC4175MDR1 and mitochondrial taxol resistance associated genetransmembrane protein 243, mitochondrialtransmembrane protein C7orf23

Not established (no approved drugs reported to target TMEM243) In cancer biology studies, TMEM243 overexpression was observed in chemoresistant cells in parallel with MDR1 (P-glycoprotein), suggesting an indirect association with drug resistance mechanisms[1]