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Transmembrane protein 247 (TMEM247)
- Target
- TMEM247
- Molecular classification
- Transmembrane protein, Other (integral membrane protein)
01
Overview
Transmembrane protein 247 is a multi-pass membrane protein encoded by the TMEM247 gene in humans. Its canonical structure predicts two transmembrane domains located near the C-terminus, with the protein likely residing in the endoplasmic reticulum membrane. The biological function of TMEM247 is not known, and it lacks significant functional characterization in available literature. Although largely expressed in the testes, studies suggest no significant role in reproduction, and only indirect or weak genetic associations with diseases such as coronary artery disease have been proposed. TMEM247 is highly conserved among land vertebrates, but its role, if any, in cellular processes, disease, or as a therapeutic target, remains undefined. No drugs are known to interact with this protein, it is not used as a biomarker, and it currently has no direct therapeutic relevance.
- Other names
- TMEM247ENSP00000343375A6NEH6 (UniProtKB accession)HGNC:42967NCBI Gene: 388946Ensembl: ENSG00000284701
02
Mechanism of action
None known; no drugs are documented to act directly on TMEM247
03
Biological functions
UnknownPossible structural or regulatory function in membrane compartmentsPredicted localization to endoplasmic reticulum
04
Disease associations
Associated with Polyposis, Skin Pigmentation, Alopecia, and Fingernail ChangesAssociated with Renal Hypodysplasia/Aplasia 1Potential but weak genetic association with coronary artery diseaseNo validated, direct disease role or recognized function in major pathologies
05
Safety considerations
None reported; no recognized therapeutic relevance or known toxicity
06
Interacting drugs
None reported
07
Biomarkers
None validated
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