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Transmembrane protein 253 is a predicted membrane protein encoded by the *TMEM253* gene on chromosome 14 and present in several splice variants[1][2][6]. Its tissue expression is granular within the cytoplasm of gastrointestinal mucosa and is detected in a wide range of organs without clear tissue specificity or disease association[4]. There are no experimental annotations for its molecular function or involvement in biological processes, and it is not considered a validated drug target, biomarker, or subject of therapeutic interest[5][7]. Its aliases include TMEM253, C14orf176, C14orf95, and NCRNA00220, and its most specific molecular classification is "transmembrane protein"[2][5][6][8].
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