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Transmembrane protein 258 (TMEM258)
- Target
- TMEM258
- Molecular classification
- Transmembrane protein, Glycosyltransferase complex subunit, Other (specifically: oligosaccharyltransferase complex component)
01
Overview
Transmembrane protein 258 (TMEM258) is a subunit of the oligosaccharyltransferase (OST) complex, which catalyzes the transfer of a glycan from dolichol-pyrophosphate to an asparagine residue of nascent polypeptide chains—a key step in cotranslational protein N-linked glycosylation. TMEM258 is localized in the endoplasmic reticulum membrane and works as part of complexes necessary for maximal OST activity. It is implicated in ER homeostasis and cellular processes relevant to epithelial cells. Disease associations include spinocerebellar ataxia 20 and chronic laryngitis. No drugs or biomarkers are directly associated with TMEM258, and it is not considered a therapeutic target in current literature.
- Other names
- C11orf10KudukKudDolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258Oligosaccharyl transferase subunit TMEM258UPF0197 transmembrane protein C11orf10Chromosome 11 open reading frame 10
02
Mechanism of action
Not applicable. There are no drugs targeting TMEM258 or known mechanism of action for direct therapeutic modulation
03
Biological functions
Protein N-linked glycosylation (catalyzes transfer of glycans to newly synthesized polypeptides during translation)ER homeostasis, especially in colonic epitheliumMay contribute to epithelial cell apoptotic processesCotranslational association with Sec61 translocon complex during protein translocation in the endoplasmic reticulum
04
Disease associations
Spinocerebellar ataxia 20Chronic laryngitisIntestinal inflammation (in mouse studies)ER stress-related conditions
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