Transmembrane protein 278 (TMEM278)

Transmembrane protein 278 (TMEM278) is an integral membrane protein encoded by the TMEM278 gene on human chromosome 1p36.33[1][11][12][13]. The protein is predicted to localize at the plasma membrane and may play a role in the negative regulation of the canonical Wnt signaling pathway, as inferred from gene ontologies and computational predictions[1][13][14]. TMEM278 is sometimes referred to by its older alias, TMEM88B. There are no well-established biological functions, animal model phenotypes, or molecular roles, and no experimental evidence links this protein as a therapeutic target in any human disease[1][12]. The disease roles described to date (such as association with Alexithymia) are not therapeutically actionable, and there are no drugs known to modulate its function. TMEM278 is currently classified as a member of the broad TMEM (transmembrane protein) family, not as a receptor, enzyme, or transporter[1][12][13][14]. There is also no evidence of TMEM278 having significant safety or biomarker roles, nor is it used for patient selection or therapy monitoring. Its function remains largely uncharacterized.

Other names

TMEM278TMEM88BTransmembrane protein 88Btransmembrane protein 278transmembrane protein 88B

Not applicable; no drugs target this protein directly