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Target intelligence / Profile preview
Transmembrane protein 42 (TMEM42)
- Target
- TMEM42
- Molecular classification
- Other (predicted to be an integral membrane protein, currently unclassified within major drug-target families)
01
Overview
Transmembrane protein 42 (TMEM42) is a protein-coding gene located on chromosome 3 in humans. It encodes a predicted integral membrane protein with 159 amino acids. The subcellular localization is suggested to be the membrane, but its molecular function and biological roles remain uncharacterized, with no direct experimental evidence for involvement in biological processes or molecular functions. TMEM42 has been associated via gene-based studies with several syndromes and disorders, including bone and developmental diseases, but the functional or causal role in these conditions has not been established. No drugs are currently reported to interact with TMEM42, and it is classified as "Tdark," indicating it is poorly characterized with limited functional data or therapeutic relevance.
- Other names
- TMEM42MGC29956Transmembrane protein 42
02
Disease associations
dacryocystitis-osteopoikilosis syndromemelorheostosisautosomal recessive hypophosphatemic rickets12q14 microdeletion syndromepyknoachondrogenesisosteomesopyknosismajor depressive disorder
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