Transmembrane protein 50B pseudogene

Transmembrane protein 50B pseudogene (ENSG00000270248) is a non-coding genomic locus with sequence similarity to the functional Transmembrane protein 50B gene (TMEM50B), but has accumulated disabling mutations and does not encode a functional protein product[7][1][3]. Pseudogenes are regarded as defunct remnants of coding genes and are generally not translated into proteins nor considered canonical therapeutic targets[1][5]. While some pseudogenes in the human genome may exhibit low-level transcription or potential regulatory roles, there is no evidence that this TMEM50B pseudogene is functional, disease-associated, or relevant for drug discovery. Its status in major gene databases confirms it is non-coding; for any functional or drug discovery analyses, the protein-coding TMEM50B gene or protein would be appropriate, not its pseudogene[7][2][6]. If you intended to refer to the functional target, use "Transmembrane protein 50B" (TMEM50B, ENSG00000142188); otherwise, the pseudogene is not a valid drug discovery or therapeutic target.

Other names

TMEM50B pseudogeneTMEM50BP (rare/informal)Transmembrane protein 50B (pseudogene)