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Target intelligence / Profile preview
Transmembrane protein 54 (TMEM54)
- Target
- TMEM54
- Molecular classification
- Integral membrane protein, Transmembrane protein, Other
01
Overview
Transmembrane protein 54 (TMEM54) is a protein-coding gene product located in cellular membranes and is predicted to play a role as a membrane/integral membrane protein[1][5][6]. It is also known as beta-casein-like protein or CAC-1, identified originally through cloning in a cervical adenocarcinoma cell line[7]. TMEM54 is associated with several cancers, including cervical adenocarcinoma and liver adenocarcinoma, but its precise molecular or physiological function remains undetermined. There is no direct evidence it acts as a classic receptor, enzyme, ion channel, transporter, or transcription factor; nor are there documented drugs or targeted therapies against it, making it more of a candidate or putative biomarker in oncology research rather than a validated therapeutic target[1][3][8].
- Other names
- Beta-casein-like proteinBCLPCAC-1CAC1Protein CAC-1cervical adenocarcinoma cell line 1 cDNA
02
Biological functions
Unknown (notably predicted to function as a membrane protein; possible generic involvement in membrane biology per the transmembrane protein family but no direct function cited for TMEM54)
03
Disease associations
CancerCervical adenocarcinomaLiver cancerAdenocarcinoma
04
Biomarkers
Not established for general clinical use; reported elevated expression in some cancers but not established as a selected biomarker
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