Transmembrane protein 87B (TMEM87B)

Transmembrane protein 87B is a eukaryotic membrane protein that structurally belongs to the GOLD domain seven-transmembrane helix (GOST) family, closely related to TMEM87A, GPR107, and GPR108[2][5]. It is specifically involved in retrograde protein trafficking within the cell, especially to and from the Golgi apparatus, and plays roles in developmental signaling and cardiac tissue development[3][4][1]. Mutations or disruptions of TMEM87B are associated with congenital heart defects and copy-number variation syndromes such as 2q13 microdeletion syndrome[4]. TMEM87B exhibits high expression in the brain and heart[4], with possible roles in certain developmental disorders and malignancies, but its function as a mechanosensitive ion channel or as a classical G protein-coupled receptor is structurally and biologically disputed[2][5]. There is no evidence that TMEM87B is a pharmacological target, and no drugs or mechanisms of action have been identified for this molecule[3][4][5].

Other names

TMEM87BFLJ14681transmembrane protein 87B

Not applicable; there are no drugs known to target TMEM87B