Transmembrane protein 89 (TMEM89)

Transmembrane protein 89 (TMEM89) is a human protein encoded by the TMEM89 gene located on chromosome 3p21.31. The protein is 159 amino acids long, with two topological domains (extracellular and cytoplasmic) and a single transmembrane α-helix. TMEM89 is structurally rich in histidine, leucine, and tryptophan, and displays conserved regions among mammals but is uncharacterized functionally. It shows highest expression in the testis, with lower levels in several other tissues, and has predicted roles in protein–protein interactions, cell signaling, cytoskeletal organization, and membrane trafficking due to the presence of domains such as a predicted SH3-binding domain, N-myristylation site, and phosphorylation site. Clinically, TMEM89 has been proposed as a possible biomarker for upper tract urothelial carcinomas and may have modulatory roles in autism spectrum disorder severity and testicular germ cell tumor prognosis, but it is not currently considered a validated therapeutic target and has no known drug modulators.

Other names

TMEM89transmembrane protein 89