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Target intelligence / Profile preview
Sigma-2 Receptor (S2R)
- Target
- S2R
- Molecular classification
- Receptor, Transmembrane protein
01
Overview
The sigma-2 receptor (S2R), encoded by the TMEM97 gene, is an integral membrane protein primarily localized to the endoplasmic reticulum and lipid rafts. It plays a role in cholesterol homeostasis, modulates neuronal signaling, and is highly expressed in proliferating cells, including tumor cells. S2R has emerged as a promising therapeutic target for neurodegenerative diseases and cancer, with preclinical studies showing that small-molecule modulators can rescue impaired biological functions.
- Other names
- TMEM97Transmembrane protein 97
02
Mechanism of action
Small-molecule modulators targeting S2R can rescue impaired biological functions
03
Biological functions
Cholesterol homeostasisNeuronal signaling modulationCell proliferationAutophagy modulationMembrane trafficking regulationOxidative stress regulation
04
Disease associations
Neurodegenerative diseaseAlzheimer’s diseaseParkinson’s diseaseCancerAge-related macular degeneration
05
Biomarkers
Cell proliferation status in solid tumors
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