Transmembrane protein adipocyte-associated 1 (TPRA1)

Transmembrane protein adipocyte-associated 1 (TPRA1), also known as GPR175, is an orphan G protein-coupled receptor (GPCR) encoded by the TPRA1 gene on chromosome 3[2][3][7][9]. It is predicted to be located primarily in the plasma membrane and is involved in G protein-coupled receptor (GPCR) signaling pathways[3][9][10]. TPRA1 has been linked to various biological processes, including the regulation of embryonic cleavage and negative control of mitotic cell cycle phase transitions[3][9]. Functional studies suggest that TPRA1 (GPR175) may play a modulatory role in signaling pathways such as the Hedgehog pathway by regulating cAMP levels[4]. Mutations or dysregulation of TPRA1 have been associated with rare diseases such as Fox-Fordyce disease and dyschromatosis universalis hereditaria[3]. As an orphan GPCR, no specific endogenous ligand is presently known, and there are no well-characterized drug interactions or established therapeutic agents targeting TPRA1 to date[3][4][9].

Other names

GPR175TMEM227TPRA40PP6566FLJ32197Transmembrane protein 227Integral membrane protein GPR175Seven transmembrane domain orphan receptorTransmembrane domain protein regulated in adipocytes 40 kDa