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Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2)
- Target
- TMEFF2
- Molecular classification
- Transmembrane protein, Proteoglycan, Growth factor receptor family
01
Overview
TMEFF2 is a type I transmembrane proteoglycan with roles in neuroprotection and cancer. It contains follistatin-like and EGF-like domains, and its expression and methylation status are altered in various cancers, making it a potential biomarker. It interacts with amyloid β derivatives and PDGF-AA, modulating cell signaling pathways.
- Other names
- HPP1Tomoregulin (TR)TENB2CT120.2TPEF
02
Mechanism of action
Modulation of cell signaling pathways (ERK, JAK/STAT)
03
Biological functions
NeuroprotectionCell proliferationApoptosis modulationGrowth factor signalingOne-carbon metabolism regulation
04
Disease associations
CancerAlzheimer's disease
05
Safety considerations
Dual role as oncogene and tumor suppressor depending on cancer typePotential for off-target effects due to interaction with multiple signaling pathways
06
Biomarkers
TMEFF2 mRNA expressionTMEFF2 protein expressionTMEFF2 promoter methylation status
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