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Transmembrane protein with metallophosphoesterase domain (TMPPE)
- Target
- TMPPE
- Molecular classification
- Transmembrane protein, Enzyme (putative, metallophosphoesterase domain), Other (as its specific functional family assignment is not well established)
01
Overview
The transmembrane protein with metallophosphoesterase domain (TMPPE) is an uncharacterized membrane protein predicted to include five transmembrane alpha-helical regions and harbors a metallophosphoesterase domain[3][5]. It is part of a broader group of 5-transmembrane domain proteins, a significant portion of which are involved in localization, membrane trafficking, or transport functions, and some act as enzymes[1]. The metallophosphoesterase domain suggests potential enzymatic activity in hydrolyzing phosphoester bonds, but no direct biochemical, physiological, or therapeutic function has been established for TMPPE itself[1][3]. TMPPE has been noted as not fully characterized, and more research is needed to define its biological role, disease relevance, and druggability[1].
- Other names
- TMPPEFLJ45032transmembrane protein with metallophosphoesterase domain
02
Biological functions
Protein localizationMembrane traffickingPotential enzymatic activity (metallophosphoesterase activity is implied by the domain but not experimentally confirmed)
03
Disease associations
Cancer (as a member of the broader 5TM protein group, many of which are cancer prognostic markers[1])Other (as a minority of 5TM proteins, including TMPPE, are not yet fully characterized[1])
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