Transmembrane serine protease 11B (TMPRSS11B)

Transmembrane serine protease 11B (TMPRSS11B) is a cell surface serine protease involved in proteolytic processes in epithelial tissues. TMPRSS11B is highly expressed in the plasma membrane and enhances lactate export by promoting the solubilization of Basigin, the chaperone for the monocarboxylate transporter MCT4, leading to increased glycolytic metabolism in cancer cells. This activity is crucial for tumorigenesis in lung squamous cell carcinoma, and high TMPRSS11B expression correlates with poor prognosis in lung cancer patients. TMPRSS11B may be a novel therapeutic target in cancer, especially because it is accessible on the cell membrane and functionally linked to metabolic pathways[1][3][8][9].

Other names

HATL5Airway trypsin-like protease 5Transmembrane protease serine 11BTMPRSS11B

Inhibition of serine protease activity (by aforementioned inhibitors)[9]. Potential interruption of metabolic reprogramming in cancer cells by blocking the solubilization of Basigin and subsequent lactate export[1].