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Target intelligence / Profile preview
Transmembrane Serine Protease 2 (None)
- Target
- None
- Molecular classification
- Enzyme, Serine Protease, Transmembrane Protein
01
Overview
Transmembrane Serine Protease 2 (TMPRSS2) is a type II transmembrane serine protease that plays a critical role in viral entry and prostate cancer. It is highly expressed in epithelial tissues, including the respiratory tract and prostate. TMPRSS2 facilitates viral entry by cleaving and activating viral envelope glycoproteins, such as the SARS-CoV-2 spike protein. In prostate cancer, TMPRSS2 can fuse with ETS transcription factors, leading to overexpression of oncogenic ETS factors. TMPRSS2 is a therapeutic target for antiviral drug development and a biomarker/fusion partner gene in oncology research.
02
Mechanism of action
Inhibition of serine protease activity; cleavage prevention of viral spike protein.
03
Biological functions
Trypsin-like serine proteolysisViral glycoprotein activationEpithelial sodium channel activationProteolytic cascadesTissue homeostasis
04
Disease associations
Viral InfectionsProstate Cancer
05
Interacting drugs
Camostat mesylate
1 more in the full profile.
06
Biomarkers
TMPRSS2-ERG fusion (prostate cancer)TMPRSS2 expression levels (viral susceptibility)
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