Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Transmembrane Serine Protease 6
- Molecular classification
- Enzyme, Serine Protease, Type II Transmembrane Protein, S1 chymotrypsin-like serine proteases
01
Overview
Transmembrane Serine Protease 6 (TMPRSS6), also known as matriptase-2, is a type II transmembrane serine protease that plays a crucial role in regulating iron homeostasis. It primarily functions by suppressing hepcidin production when blood iron levels are low, thereby increasing dietary iron absorption and mobilization from storage sites. Mutations in TMPRSS6 are associated with iron-refractory iron deficiency anemia (IRIDA), a condition characterized by chronic anemia due to unregulated high levels of hepcidin.
- Other names
- Matriptase-2Transmembrane protease serine 6
02
Mechanism of action
Inhibition of TMPRSS6 activity to increase hepcidin production (not clinically available)
03
Biological functions
Regulation of hepcidin expressionIron homeostasisCleavage of hemojuvelin (HJV)Regulation of BMP/SMAD pathway
04
Disease associations
Iron-Refractory Iron Deficiency Anemia (IRIDA)
05
Safety considerations
Potential for off-target effects due to serine protease activityUnintended consequences of altering iron homeostasisResistance to oral iron therapy in IRIDA patients
06
Biomarkers
Hepcidin levelsSerum ironTransferrin saturationHemoglobin levelsTMPRSS6 mutations
Beyond the preview
Go deeper on Transmembrane Serine Protease 6.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Transmembrane Serine Protease 6.