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Target intelligence / Profile preview
Bacterial Cell Wall Peptidoglycan Cross-Linking Enzyme (PBP)
- Target
- PBP
- Molecular classification
- Enzyme, Transferase
01
Overview
The bacterial cell wall peptidoglycan cross-linking enzyme is a critical catalyst in the final stages of bacterial cell wall biosynthesis. Its main function is to form peptide cross-links between glycan strands in the peptidoglycan layer, providing structural integrity and rigidity to the bacterial cell wall. This process is essential for maintaining cell shape and protecting bacteria from osmotic lysis. Key enzymes include transpeptidases (Penicillin-Binding Proteins, PBPs) and LD-transpeptidases, which are targets for β-lactam antibiotics. Variations or mutations can confer antibiotic resistance.
- Other names
- TranspeptidasePenicillin-Binding ProteinDD-transpeptidaseLD-transpeptidase
02
Mechanism of action
Inhibition of peptidoglycan cross-linking, leading to weakened cell walls and bacterial lysis
03
Biological functions
Cell wall biosynthesisPeptidoglycan cross-linkingCell shape maintenanceBacterial survival
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Antibiotic resistance developmentAllergic reactions to β-lactam antibiotics
06
Interacting drugs
Penicillins
2 more in the full profile.
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